![]() ![]() 1 CNP is a paracrine/autocrine peptide expressed in many tissues, 2 including endothelial cells. Moreover, we found indications of sex differences in pro-CNP concentrations over time (higher pro-CNP in males (4.4, 95% CI −0.28 to 9.1 pmol/L, p=0.07) and interaction of sex and time (p=0.13)), and that hypertension was independently associated with higher pro-CNP (4.5, 95% CI 0.6 to 8.4 pmol/L, p=0.03).ĭespite the structural resemblance to the cardiac hormones, atrial A-type natriuretic peptides (ANP) and B-type natriuretic peptides, C-type natriuretic peptide (CNP) differ functionally from the two other family members. ![]() After adjusting for potential risk factors, we found increased pro-CNP concentrations≥the median value to be independently associated with increased risk of mortality in female patients within 1 year (HR per 1 pmol/L increase: 1.04, 95% CI 1.01 to 1.06, p=0.007). In separate sex-stratified analyses, female patients showed increased all-cause mortality (HR 1 year 2.6, 95% CI 1.5 to 4.6), P logrank <0.001), whereas no differences were found in male patients (HR 1 year 1.1, 95% CI 0.7 to 1.9, P logrank=0.66). ![]() In all patients, an increased pro-CNP concentration was associated with a higher all-cause mortality after 1 year (HR 1.6, 95% CI 1.1 to 2.4, P logrank=0.009) including an interaction of sex (p=0.03). ![]()
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